These guidelines were published in 2021 as a collaboration between The American Society of Hematology (ASH), the International Society on Thrombosis and Haemostasis (ISTH), the National Hemophilia Foundation (NHF), and the World Federation of Hemophilia (WFH) and are intended to support patients, clinicians, and other health care professionals in their decisions about VWD diagnosis and management.

The two guidelines are:
ASH ISTH NHF WFH 2021 guidelines on the diagnosis of von Willebrand disease
ASH ISTH NHF WFH 2021 guidelines on the management of von Willebrand disease