The World Federation of Hemophilia (WFH) developed the first edition of the Guidelines for the Management of Hemophilia in 2005. These guidelines were updated in 2012 and again in 2020 and have since been distributed globally in print and online.

For the third edition (2020), the WFH modified the development method, incorporating evidence-based and Trustworthy Consensus-Based Statement (TCBS) approaches alongside established international standards for clinical practice guidelines to create an evidence-based and consensus-driven approach.

Guideline panels are composed of hemophilia experts from around the world, including individuals with lived experience. The process includes structured clinical question development, application of the PICO methodology, systematic literature reviews and appraisal and synthesis of the evidence, complemented by expert clinical input. This ensures that recommendations are scientifically robust, clinically meaningful, and relevant across diverse global settings.

In 2025, the WFH advanced its methodology by incorporating a Living Guideline Model (LGM), ensuring recommendations are updated as new evidence emerges and remain relevant for the global hemophilia community. The LGM model is supported by increased transparency in the development process, a formalized Evidence-to-Decision (EtD) Framework, and enhanced supplemental materials including educational tools and webinars. All guidelines content and supporting resources are now integrated into this new Guidelines Hub, providing streamlined access to the full development process and the most up-to-date recommendations.